ENGINEERING APTAMER-DIRECTED PHOSPHATASE RECRUITING CHIMERAS: A STRATEGY FOR MODULATING RECEPTOR FUNCTION AND OVERCOMING DRUG RESISTANCE

Engineering aptamer-directed phosphatase recruiting chimeras: a strategy for modulating receptor function and overcoming drug resistance

Abstract Receptor tyrosine kinases (RTKs) play a crucial role in the regulation of intracellular signal transduction, underscoring their significance as targets for drug therapy.Despite the widespread clinical use of kinase inhibitors, the increasing occurrence of off-target effects and drug resistance makes it urgent to explore alternative approac

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Development of a comprehensive noninvasive prenatal test

Abstract Our aim was to develop and apply a comprehensive noninvasive prenatal test (NIPT) by using high-coverage targeted next-generation sequencing to estimate fetal fraction, determine fetal sex, and detect trisomy and monogenic disease without parental genotype information.We analyzed 45 pregnancies, 40 mock samples, and eight mother-child pair

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